Amide Formation using ‘Catch and Release’
This Application Note illustrates how the R-2 pump/injector and R-4 flow reactor modules can be used to prepare amides uilising polymer-assisted continuous flow-through (PACT) chemistry.1
In this example, 4-bromobenzoic acid 1 is ‘captured’ by a beaded polystyrene PACT reactor as an immobilised active ester derivative. Elution with 2-phenylethylamine 2 then promotes ‘release’ of the amide adduct 3 into the flow stream. Notably, where the amine is the limiting reagent, the amide 3 is obtained directly in high purity. However, any remaining unreacted amine can be removed in- line by elution through a sulfonic acid scavenger cartridge prior to sample collecion.
Setup:
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