Suzuki Coupling with SiliaCat DPP-Pd Heterogeneous Catalyst
This report describes a Suzuki coupling with:
- Short residence time of 1 minute, 15 seconds
- With > 95% conversion
- High reaction yield
The Suzuki-Miyaura palladium coupling is used in a wide range of syntheses of biaryl and heterobiaryl products throughout the pharmaceutical and fine chemical industries. Typically, in batch, the Suzuki coupling cannot be performed above the boiling point of the reaction solvent, which can result in long reaction times, however flow chemistry permits higher operating pressures with greatly improved safety, allowing higher reaction temperatures, and faster reactions times.
Catalyst stability is an important consideration when performing heterogeneous reactions at higher temperature, which led to the selection of the SiliCycle SiliaCat DPP-Pd heterogeneous catalyst; a commercially available sol-gel entrapped catalyst. The SiliaCat DPP-Pd is ideal for continuous flow Suzuki couplings, with good thermal stability (max. temperature 125 °C), air-stable and significantly, not susceptible to swelling in the presence of organic solvents.
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