Further photochemical hydrogenations of nitro compounds
Abstract
This application note builds upon the previous application note 41’s green photochemical reductions. Extending the range of aromatic nitro compounds, including the hydrogenation of a Linezolid intermediate (Pfizer brand name Zyvox), and demonstrating excellent adaptability for the varying chemical properties. Vapourtec’s efficient and precise generation 2 LED (Gen-2) was the sole light source used, allowing accurate and uniform 365 nm irradiation while providing impressive throughput. The optimized condition for each reduction was quickly achieved; residence time, concentration and reaction temperature were modified to maximize throughput while concurrently achieving close to 100% conversion to desired product. The aim of this work was to showcase the capability of the Vapourtec’s E-Series when used in combination with the UV-150 photochemical reactor.
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