Synthesis of Artemisinin via the Photooxidation of Dihydroartemisinic Acid
Submitted by: Dr. Kerry Gilmore of the Max Planck Institute for Colloids and Interfaces, Biomolecular Systems Department.
This application note illustrates the use of the new Vapourtec UV-150 reactor which allows access to continuous photochemistry in an easy-to-use, safe and efficient manner.
This application note demonstrates the use of the UV-150 photochemical reactor and E-Series system in the continuous synthesis of Artemisinin via the photooxidation of dihydroartemisinic acid. The chemistry has been previously demonstrated delivering oxygen via a mass flow controller in a ‘home-made’ system; this application shows that the easy-Photochem system can deliver not only the substrate but also oxygen in a safe, efficient continuous manner with the UV-150 effectively generating the singlet oxygen required for the reaction. This self-contained unit, coupled to an additional room temperature reactor is shown to synthesise the anti-malarial medicine artemisinin in comparable yields to previously published methods.
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