E-Series 一 Reaction of Grignard Reagents under Continuous Flow Conditions
This application note illustrates the use of the Vapourtec E-Series system to run reactions such as Grignard reactions under continuous flow conditions for extended periods with no pump issues.
Continuous flow chemistry offers easy access to scaling reactions from milligrams to kilograms, and many successful examples have been well documented. The Vapourtec E-Series system is a new flow chemistry system that offers simplicity and robustness to the range of available flow chemistry apparatus. The unique pumping system allows reliable and smooth pumping across a wide range of flow rates and is capable of pumping strong acids, light suspensions and organometallic reagents as we will demonstrate. The pumping system also allows consecutive immiscible solvents to be pumped offering a distinct advantage to commonly used methods. The self-priming mechanism allows this system to be up and running in a matter of minutes.
The Grignard reaction was discovered over a hundred years ago and continues to be an important reaction in the synthetic chemist’s tool kit. The Grignard reaction is traditionally described as the reaction between an alkyl- or aryl-magnesium halide adding to the carbonyl group in an aldehyde or ketone. Grignard reagents however show excellent reactivity to a wide range of electrophiles such as thiols, imines and nitriles making them extremely versatile in C-C bond formation.
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