High Pressure and Temperature Process Scale SNAr Reaction under Solvent Free Conditions using Liquefied Dimethylamine
This application note illustrates the use of the Vapourtec R-Series system to run reactions under solvent free (neat) conditions and it’s ability to pump liquefied gases at high temperatures and pressures. This expands on work carried out in Application note 29 (where a game changing throughput of material from a bench top system was demonstrated).
By harnessing the higher temperatures and pressures available and again running the reaction solvent free it is possible to carry out uncatalysed amination of 2-chloropyridine in throughput previously unavailable.
Using the Vapourtec High Pressure Pump Module when carrying out reactions of this nature removes limitations associated with batch pressure reactors (e.g. Parr ‘bombs’).
| 產品型錄
Vapourtec 產品型錄下載
【Vapourtec】官網
