Michael Addition of Nitromethane to a Cinnamate Ester
This example illustrates the use of the Vapourtec R-Series flow chemistry platform to safely process an extremely energetic, reactive intermediate.
The use of nitromethane in the pharmaceutical laboratory is often limited due to its reactive exothermic nature when deprotonated. This example illustrates how limiting the tube reactor size limits the hazardous nature of this reaction.
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