Array Synthesis using Loop Injection and a Tubing Reactor Combined with a Scavenger Column
This Application Note illustrates how the R-2+ pump/injector and R-4 flow reactor modules can be used in combination with a tubing reactor and a PACT scavenger column to perform sequential array synthesis employing simultaneous loop injection. Excess starting material 2{n} is used to drive the SNAr reaction with the aryl fluoride 1 to completion by incubation in the tubing reactor. The remaining amine is then scavenged prior to collection of the product 3{n}.
Where the capacity of the scavenging column exceeds the scale of the reaction, the reaction may be repeated in a sequential manner varying the monomers used in each cycle to afford a compound array 3{n} such that each compound is obtained directly in high purity. Moreover, depending upon the choice of the scavenger, an excess of either starting material may be removed by selective in-line scavenging.
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