One example of a reaction with a challenging mixing behaviour is an ester synthesis via a Steven’s oxidation, which uses aqueous sodium hypochlorite to oxidise an aldehyde to an ester in the presence of an alcohol, allowing the direct synthesis of the ester from the aldehyde.
The Suzuki-Miyaura palladium coupling is used in a wide range of syntheses of biaryl and heterobiaryl products throughout the pharmaceutical and fine chemical industries.
This application note demonstrates the preparation of cage compound 2 from an advanced diene precursor 1, which can be prepared from cyclopentanone.
This application note uses the photochemical reaction explored in application note 36, the photocycloaddition of maleimide and 1-hexyne, to explore the performance of Vapourtec’s new low pressure mercury lamps.
This application note expands on the work described in application notes 41 and 42 describing a photochemical hydrogenation using an immobilized photo catalyst.
This application note demonstrates the oxidation of thioanisole using hydrogen peroxide in continuous flow. It highlights the use of 50 wt% hydrogen peroxide which can be pumped neat with Vapourtec systems.
This application note demonstrates the potential throughput capabilities of the UV-150, using an uncatalysed, intramolecular photochemical [2+2] cycloaddition.
This application note demonstrates the use of singlet oxygen in flow, investigating a range of parameters which can affect the conversion and throughput.
This application note builds upon the previous application note 41’s green photochemical reductions.
Photo catalyzed nitro reductions have previously been published under batch conditions leading to a time consuming and somewhat inefficient process.
