One example of a reaction with a challenging mixing behaviour is an ester synthesis via a Steven’s oxidation, which uses aqueous sodium hypochlorite to oxidise an aldehyde to an ester in the presence of an alcohol, allowing the direct synthesis of the ester from the aldehyde.

The Suzuki-Miyaura palladium coupling is used in a wide range of syntheses of biaryl and heterobiaryl products throughout the pharmaceutical and fine chemical industries.

This application note demonstrates the preparation of cage compound 2 from an advanced diene precursor 1, which can be prepared from cyclopentanone.

This application note uses the photochemical reaction explored in application note 36, the photocycloaddition of maleimide and 1-hexyne, to explore the performance of Vapourtec’s new low pressure mercury lamps.

This application note expands on the work described in application notes 41 and 42 describing a photochemical hydrogenation using an immobilized photo catalyst.

This application note demonstrates the oxidation of thioanisole using hydrogen peroxide in continuous flow. It highlights the use of 50 wt% hydrogen peroxide which can be pumped neat with Vapourtec systems.

This application note demonstrates the potential throughput capabilities of the UV-150, using an uncatalysed, intramolecular photochemical [2+2] cycloaddition.

This application note demonstrates the use of singlet oxygen in flow, investigating a range of parameters which can affect the conversion and throughput.