Continuous Fluorination Reaction with Diethyl Amino Sulfur Trifluoride (DAST)
This application note illustrates the use of the Vapourtec R-Series system to pump highly reactive, moisture sensitive reagents in a safe and stable continuous reaction. Here we describe the continuous fluorination of a carbonyl group with diethylaminosulfurtrifloride (DAST) pumping directly through the R-Series acid resistant pump heads.
The addition of fluorine into pharmaceuticals and agrochemicals is an area of high importance and is illustrated by the number of top selling drugs containing fluorine (15 out of the top 100 selling pharmaceuticals by worldwide sales 2009). Its application also includes polymers and materials, specialty solvents, performance fluids and in numerous reagents and intermediates for chemical synthesis
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