Heterocycle Formation in Flow: 4, 5 – Disubstituted Oxazoles
This Application Note illustrates how the R-2 pump/injector and R-4 flow reactor modules can be used to prepare oxazoles utilising a combination of a tubing reactor and polymer-assisted continuous flow-through (PACT) reactors.1 Reagents are introduced into the flow stream via sample loops attached to the injection valves.
In this example, benzoyl chloride 1 is mixed with ethyl isocyanoacetate 2 and incubated at 50oC in a tubing reactor before elution through a PS-BEMP PACT reactor, also at 50oC, to promote 4,5- oxazole formation. The outflow from the reactor passes through a Quadrapure BZA PACT scavenger column to effect in-line purification before the 4,5-disubstituted oxazole product 3 is collected with high purity using an automated fraction collector.
Setup:
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